Once your doctor prescribed you the medication, it is up to you to choose a brand or generic Crestor. The prices of generics are low enough in internet pharmacies, so patients tend to buy Crestor online due to affordable Crestor cost.
What is Crestor Rosuvastatin?
Rosuvastatin, also marketed as Crestor, is an anticholesterol drug which, when used in combination with exercise and diet, helps to lower cholesterol level and prevent vascular heart disease. It is mainly prescribed to adults and sometimes to children over 10 years old with high cholesterol level. The drug’s primary use is the treatment of dyslipidemia.
What is the price of generic Crestor?
Once your doctor prescribed you the medication, it is up to you to choose a brand or generic Crestor. The prices of generics are low enough in internet pharmacies, so patients tend to buy Crestor online due to affordable Crestor cost. Generic drugs are almost identical or within an acceptable bio-equivalent range to the brand with the only difference that they are produced by different manufacturers and Crestor price varies as well.
Shall I gain weight with Crestor?
Weight gain isn’t a common complaint with anticholesterol drugs. Moreover, generic Crestor is usually prescribed together with diet and bodily exercises. So, don’t be afraid to gain weight with this drug.
Will Crestor help to lose weight?
Being overweight can increase the cholesterol level in your body, and conversely, weight loss can help reduce bad cholesterol level. Generic Crestor works by blocking the enzyme that helps create cholesterol in the body. Physical exercise and a healthy diet may be effective for some patients in weight loss. Besides, one of the drug’s side effects is loss of appetite which will also contribute to the weight loss.
What is generic Crestor dosage?
The drug should be taken exactly as prescribed by your physician. If not administered otherwise, the usual starting dose is 10 mg. The dosage may range from 5 to 40 mg orally once a day. It can be taken as a single dose at any time of the day with or without food. The drug may be needed to be taken on long-term basis, so discuss Crestor cost with you healthcare provider.
What are possible generic Crestor side effects?
Report to your physician if you experience any of the following side effects: constipation, joint pain, confusion, cough or dizziness. Stop taking the drug and address to your doctor if you have unexplained muscle pain, swelling, allergic reactions, dark colored urine, bleeding or bruising.
Can I drink alcohol while receiving generic Crestor?
As a rule, it is safe to consume a moderate amount of alcohol while taking generic Crestor. But it is not recommended for people with liver disease. The drug is also not recommended for people consuming alcohol in large amounts on regular basis. Discuss this with your attending physician even if you buy Crestor online.
Who makes Crestor?
The drug was first developed by Shionogi and the pharmaceutical company AstraZeneca markets it as Crestor. The generic alternatives are not manufactured by the company that makes the brand product and Crestor price is lower. Cheap Crestor is also produced by pharmaceutical companies in India and elsewhere and is marketed by Cipla Pharmaceuticals or Rozustat.
What is Rosuvastatin?
The rosuvastatin group belongs to the drugs called statins . It is used to change the concentrations of fats in the blood called lipids , the most famous of which is cholesterol . There are different types of cholesterol, the bad LDL cholesterol and good HDL-C .
Rosuvastatin can reduce bad cholesterol and increase good.
This is one of the two statins have proven effective in reducing the risk of occurrence of cardiovascular disease by preventing primary (that is to say in the subject never had this type of disease), and that, while the level of cholesterol is low before treatment. The drop remains low (2 years) and the importance of lowering cholesterol can raise questions in terms of safety. There is also an increased risk of developing diabetes , but the decrease in cardiovascular risk persists even in these last four.
Like other statins, it may also reduce the risk of developing atrial fibrillation in some cases.
Rosuvastatin is the sixth drug molecule sold in value terms in 2012, with a projected figure of $ 7 billion.
What is Statins: atorvastatin, rosuvastatin and other?
The statins (or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents used as drugs to lower cholesterol levels of people at risk of cardiovascular disease because of their high cholesterol.
- the atorvastatin (1997)
- the fluvastatin (1994)
- the lovastatin , the oldest (1987), now almost obsolete and pulled the red yeast rice 1
- the pravastatin (1991)
- the rosuvastatin , the most recent (2003)
- the simvastatin (1988)
Statin withdrawn from the market:
the cerivastatin (1998), withdrawn in 2001 because of its severe side effects (high number of cases of rhabdomyolysis with acute renal failure and death), especially in combination with fibrates.
Using of Generic Crestor
These molecules are effective in reducing cholesterol in the blood, especially the rate of LDL-cholesterol .
They reduce the risk of occurrence ( prevention primary, especially in cases of chronic renal failure beginner) or recurrence (secondary prevention) of disease resulting from narrowing or occlusion of arteries ( myocardial infarction, angina pectoris, peripheral arterial disease of the lower limbs, stroke). This effect is objectified regardless of initial cholesterol levels: if this is normal or low, the administration of statin further reduces LDL-cholesterol and the risk of cardiovascular disease.
A meta-analysis incorporating seven clinical trials with 42,848 patients randomizes from the population shows no significant reduction in mortality, perhaps by a lack of power or too short tests or simply lack of real effect on the reduction of mortality (among these patients, at least 80% were not aware of having cardiovascular disease (coronary heart disease, cerebrovascular disease, or peripheral vascular disease), and they were followed for an average of 4.3 years). However, it shows a decrease in major coronary events, cerebrovascular events and revascularizations (being a medical procedure to allow new tissue perfusion).
Another meta-analysis showed a reduction in mortality from any cause in the group taking the statin, and a reduction in major cardiovascular events and revascularization without excess cancers or muscle pain. However, this meta-analysis of 34 272 patients focused more on patients with other cardiovascular risk factors: eleven of the fourteen randomizes trials included in the meta-analysis included patients with an increase of lipids or diabetes, a hypertension or microalbuminuria.
There are many studies on the effectiveness (or ineffectiveness) of either of statins on one or more parameters. It is currently not completely clear whether possible reduction of cardiovascular risk is a result of “class” (all statins are equivalent), or if each molecule has a specific effect, which may differ in its effectiveness.
Statins are for people suffering from familial hypercholesterolemia (as a result of a rare genetic mutation in the gene encoding the LDL receptor) a major step in restoring a life expectancy comparable to those achieved in non- part of a comprehensive primary prevention (diet, physical activity, controlling for other risk factors for cardiovascular).
Pharmacology of Generic Crestor
Metabolism is the liver. A number is metabolized through the cytochrome p450 (Lovostatine, Simvastatin, Atorvastatin, Fluvastatin to a lesser degree), which makes them susceptible to drug interactions. Grapefruit juice may interfere with the action of these statins, by acting on the cytochrome p450. It is not recommended to take drugs and drink grapefruit juice (containing naringérine).
There are two types of statins: hydrophilic and hydrophobic them. It is the second which showed the highest toxicity (liver and muscle).
Several genes (and their mutations) influence the effectiveness of statins in reducing blood cholesterol: it is essentially the HMGCR (encoding the enzyme 3-Hydroxy-3-methylglutaryl coenzyme A reductase) and APOE. Some mutations in the HMGCR reduce the activity of simvastatin 14 and pravastatin 15 but not of atorvastatin. A mutation in the APOE appears to affect all statins. A time, allele KIF6 (encoding the enzyme kinesin-like protein) appeared associated with greater efficiency in terms of morbidity and cardiovascular mortality. This has not been confirmed by subsequent studies.
Choosing a statin
Under treatment with statins, some are better valued than others.
Secondary prevention for reducing morbidity and mortality in patients with an LDL too high statins choose priority are pravastatin, simvastatin, atorvastatin or cerivastatin, other statins have not shown their effectiveness in this sense (not that the studies are negative but because they have not been made or published).
Statins are the oldest statins on which one has the most recoil, more information at the level of side effects and those that are available in generic cheapest.
There are few studies comparing statins them. These studies are difficult to conduct and interpret than against placebo. It seems, however, that statins given a standard dose (simvastatin 40 mg) is as effective as other statin deemed most effective for lowering cholesterol and given high doses (atorvastatin 80 mg) in the prevention of cardiac risk when LDL cholesterol is low base 30 .
The effectiveness in lowering cholesterol and LDL-cholesterol appears varies according to the statin selected but the data come mainly from separate studies and not direct comparisons between different statins on the same population. Thus, the usual maximum dose, making it the most statins lower LDL are, in descending order, rosuvastatin , the atorvastatin , the simvastatin , the pravastatin and fluvastatin.
Interactions, side effects
Statins are sources cramps , especially in sports
With plants or supplements
The effects of statins may be added to those of plants and supplements that reduce cholesterol.
The effects of statins may be added to those of other drugs lowering blood lipid levels.
The risk of myopathy associated with statins are increased by certain medications that increase serum statin (by decreasing the metabolism of statins): cyclosporine ( immunosuppressant ), fibrates ( hypolipidemic ), macrolides , azoles (especially ketoconazole and , itraconazole ), nefazodone ( an antidepressant ) and viral protease inhibitors (used to treat AIDS ).
Statins move the AVK their site binding to plasma proteins, which increases the free fraction of the AVK and increases the risk of bleeding.
Space statin and consumption of grapefruit juice 45 at least two hours.
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